Microfluidic devices have emerged as an innovative tool for single-cell analysis applications, but their success depends on the ability to retain cells in the cultivation chamber. Cell loss during long-term cultivation has been a significant challenge for microfluidic chips, limiting the ability to perform reproducible...
Abstract "Accurate assessment of cell stiffness distribution is essential due to the critical role of cell mechanobiology in regulation of vital cellular processes like proliferation, adhesion, migration, and motility. Stiffness provides critical information in understanding onset and progress of various diseases, including metastasis and differentiation of...
Abstract "Severe non-healing infections are often caused by multiple pathogens or by genetic variants of the same pathogen exhibiting different levels of antibiotic resistance. For example, polymicrobial diabetic foot infections double the risk of amputation compared to monomicrobial infections. Although these infections lead to increased morbidity...
The spatial organization and cellular microenvironment of the cells can be very important when it comes to RNA sequencing. Therefore, preserving the spatial organization of the cells and monitoring the changes in the cellular surrounding can be crucial for transcriptomic profiling. Droplet-based microfluidics is an...
Scale-down reactors are essential for generating data on small scale and applying the observed improvement to larger and industrial scales. Microfluidic devices can be of great use in this sense. The reaction conditions could be carefully monitored while the volume of the reaction is scaled...