Single-cell RNA sequencing (scRNA-seq) has ushered in a new era of biological understanding by enabling the assessment of gene expression profiles at the individual cell level. This advancement has illuminated the complexities of cellular heterogeneity and functional diversity within biological systems. Yet, the pursuit...
Scientists have developed a new lab-on-a-chip device that can detect single molecules of microRNA in single cells. The device, which combines microfluidics and microarray technologies, can isolate and lyse cells and detect specific miRNA on a single chip. The method does not require nucleic acid...
In the fight against cancer and other diseases, understanding the behavior and characteristics of individual cells within tissues is critical. Traditional methods of studying cells, such as flow cytometry and histology, are limited by their inability to capture both the physical and functional properties of...
Microfluidic devices have emerged as an innovative tool for single-cell analysis applications, but their success depends on the ability to retain cells in the cultivation chamber. Cell loss during long-term cultivation has been a significant challenge for microfluidic chips, limiting the ability to perform reproducible...
Abstract "Accurate assessment of cell stiffness distribution is essential due to the critical role of cell mechanobiology in regulation of vital cellular processes like proliferation, adhesion, migration, and motility. Stiffness provides critical information in understanding onset and progress of various diseases, including metastasis and differentiation of...