Abstract "The patient population suffering from pancreatic ductal adenocarcinoma (PDAC) presents, as a whole, with a high degree of molecular tumor heterogeneity. The heterogeneity of PDAC tumor composition has complicated treatment and stalled success in clinical trials. Current in vitro techniques insufficiently replicate the intricate stromal...
The complex process of human pregnancy begins with the crucial step of embryo implantation. This involves the intricate interaction between the embryo's trophoblast cells and the maternal endometrium. A groundbreaking study published in Nature Communications has developed an advanced microfluidic chip, termed "implantation-on-a-chip", to simulate...
In the ever-evolving field of microfluidics, researchers are continually pushing the boundaries to understand complex biological phenomena. One such groundbreaking study, recently published, delves deep into the intricate pathways of multiple myeloma (MM) cancer cells within the bone marrow using a meticulously engineered microfluidic chip. Microfluidic...
Organ-on-a-chip microfluidic devices are well known for their abilities in mimicking in vivo conditions and their superiority in drug toxicity screening compared to regular cell culture models. In this week's research highlight, we will introduce another organ-on-chip that takes advantage of microfluidics technology to mimic...
"Microhabitat conditions determine the magnitude and speed of microbial processes but have been challenging to investigate. In this study we used microfluidic devices to determine the effect of the spatial distortion of a pore space on fungal and bacterial growth, interactions, and substrate degradation. The...