A major challenge in drug development pipeline lies in avoiding organ-specific toxicity. Microfluidic in vitro models for drug toxicity screening such as organ on chips can play an important role in this sense by providing robust methods for evaluating cellular responses in a controllable microenvironment....
Abstract "Microphysiological systems (MPS), also referred to as tissue chips, incorporating 3D skeletal myobundles are a novel approach for physiological and pharmacological studies to uncover new medical treatments for sarcopenia. We characterize a MPS in which engineered skeletal muscle myobundles derived from donor-specific satellite cells that...
Abstract "The pH value in the wound milieu plays a key role in cellular processes and cell cycle processes involved in the process of wound healing. Here, a microfluidic assembly technique is employed to fabricate micro-gel ensembles that can precisely tune the pH value of wound...
Abstract "A comparatively straightforward approach to accomplish more physiological realism in organ-on-a-chip (OoC) models is through substrate geometry. There is increasing evidence that the strongly, microscale curved surfaces that epithelial or endothelial cells experience when lining small body lumens, such as the alveoli or blood vessels,...
Mechanobiological cues can be of crucial importance after an injury for regulating wound angiogenesis. However, mechanoregulation of angiogenesis is not fully understood in wound healing. Microfluidics has shown to be the optimal choice when it comes to mimicking the cellular microenvironment and investigating the effect...