Skin, our body's largest organ, provides us with an intricate network of sensory nerve fibers, enabling the sensation of touch, temperature, and pain. The conversation between skin cells and nerves is a critical part of skin health and disease, making the development of reliable in...
Understanding the interactions among various cells and neighboring microenvironmental components in the skin is essential for research and development and industrial applications, but challenges have existed in reconstituting 3D structures of cutaneous innervation in vitro and developing analysis tools in a cell-type-specific manner. Researchers at...
Microfluidic devices have emerged as powerful tools for studying biological processes with high precision and control. In cancer research, the incorporation of a functional vascular system is essential to accurately model the tumor microenvironment and evaluate potential anti-cancer therapeutics. To address this challenge, researchers have...
Abstract "Microfluidic-based cell culture allows for precise spatio-temporal regulation of microenvironment, live cell imaging and better recapitulation of physiological conditions, while minimizing reagents’ consumption. Despite their usefulness, most microfluidic systems are designed with one specific application in mind and usually require specialized equipment and expertise for...
Abstract "Herpes simplex virus (HSV) naturally infects skin and mucosal surfaces, causing lifelong recurrent disease worldwide, with no cure or vaccine. Biomimetic human tissue and organ platforms provide attractive alternatives over animal models to recapitulate human diseases. Combining prevascularization and microfluidic approaches, we present a vascularized,...