Despite the significant advancements brought by immune checkpoint inhibitors (ICIs) in melanoma treatment, patient responses are widely varied. Researchers suspect that the gut microbiome plays a significant role in influencing these responses. The study introduces an innovative microfluidic chip model that mimics the human...
In the ever-evolving landscape of biochemical research, protein complexes characterization plays an important role in understanding the intricate mechanisms governing cellular functions. Traditional methods, while effective, often fall short when it comes to handling low-input samples or preserving the native states of protein complexes during...
Understanding of a protein’s true behavior in biological systems remains a cornerstone for understanding biological functions and addressing diseases. Traditional methods, while useful, often fall short when it comes to dealing with proteins in their natural, or native, states—particularly when these proteins are polydisperse or...
Pancreatic cancer, notorious for its poor prognosis and rapid progression, remains a significant challenge in oncology. The complexity of pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), necessitates innovative research approaches to understand and combat this deadly disease. A recent microfluidic chip reported in Biomacromolecules journal...
Understanding how microglia, the brain's immune cells, respond to inflammation is pivotal for grasping the complexities of neurological diseases. Traditional methods, though useful, often fall short in replicating the dynamic environments of living tissues. The development of a novel microfluidic platform, marks a significant leap...