Pancreatic cancer-on-chip incorporates patient-derived organoids for drug efficacy analysis

“Here, we combine an acoustically driven manipulation device with a micro-force sensor to freely rotate biological samples and quantify mechanical properties at multiple regions of interest within a specimen. The versatility of this tool is demonstrated through the analysis of single Lilium longiflorum pollen grains, in combination with numerical simulations, and individual Caenorhabditis elegans nematodes.”, the authors explained.

“In this study, we showed that successful isolation of axons from somas and dendrites combined with the robust axonal outgrowth of hPSC-derived and rat primary cortical neurons in a compartmentalized microfluidic PDMS device is greatly influenced by the cross-sectional area and the length of the separating microtunnels. Furthermore, we created an hPSC-derived neuron-based axonal model consisting of a compartmentalized PDMS microtunnel chip integrated with photoinscribed nanotopography on light-responsive, azobenzene-based molecular glass.”, the authors concluded.