Researchers at the University of Leeds have developed a microfluidic chip for evaluating microbubble-assisted drug delivery to spheroids. The microfluidic device helped in creating a physiologically relevant in vitro condition for trapping and culturing tumor spheroids and subjecting them to microbubble guided drug delivery. The...
[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_column_text]Tissue slices are precision-cut organ slices that are commonly used for metabolism and toxicity research due to their advantages such as maintaining cell-type diversity and preserving the organ cytostructure as well as the metabolic enzymes. A major issue is...
Microfluidic single-cell analysis platforms often take advantage of droplet microfluidic for encapsulating the cells within nL-pL droplets at high throughputs. Depending on the target outcome (genomics, epigenomics, transcriptomics, etc.), specific protocols are available for the tests.Cells in a culture can be highly heterogeneous and impose...
Undoubtedly, microfluidics has opened many new windows of opportunities for single-cell analysis. Droplet microfluidics, for example, has shown great promises for encapsulation, manipulation, and incubation of single-cells within nL-pL droplets at very high throughputs. As the field grows more and more methods get developed providing...
It was only less than 100 years ago that Sir Hans Adolf Krebs measured the metabolism rate of muscle cells by exposing fresh pigeon breast meat to different reagents to discover the Krebs cycle (also known as citric acid cycle or tricarboxylic acid cycle or...