In tissue engineering, the creation of a vascular network within organoids that can efficiently supply nutrients and oxygen while removing waste is a significant challenge. Most tissues thicker than 400 µm require such a network to prevent necrosis. Traditionally, organoids are often transplanted into host...
In the continuous search to understand life's origins and harness biotechnology's potential, scientists have made a new discovery using high-throughput droplet microfluidics: a minimalist enzyme, derived from a library of de novo designed proteins, exhibiting remarkable biological activity. This enzyme, named mini-cAMPase, challenges our understanding...
Recent advancements in the field of tissue engineering have yielded a novel culture system that significantly enhances the fabrication of human cardiac tissues. This system integrates a microfluidic platform with a heart extracellular matrix (HEM) hydrogel, designed to foster the maturation of tissues that more closely...
The ability to analyze individual cells allows scientists to uncover a wealth of information hidden in the cellular heterogeneity of tissues, leading to breakthroughs in understanding diseases and developing targeted treatments. However, despite the critical importance of this research, traditional methods of single-cell analysis, particularly...
In the world of microfluidics, where controlling and monitoring the flow of liquids through channels no thicker than a human hair is critical, the development of an microfluidic pressure sensor marks an important advancement. This sensor, born from the collaborative effort of international research team...