Abstract "A comparatively straightforward approach to accomplish more physiological realism in organ-on-a-chip (OoC) models is through substrate geometry. There is increasing evidence that the strongly, microscale curved surfaces that epithelial or endothelial cells experience when lining small body lumens, such as the alveoli or blood vessels,...
Mechanobiological cues can be of crucial importance after an injury for regulating wound angiogenesis. However, mechanoregulation of angiogenesis is not fully understood in wound healing. Microfluidics has shown to be the optimal choice when it comes to mimicking the cellular microenvironment and investigating the effect...
Abstract "Circulating tumor cells (CTCs) survive in the bloodstream and then seed and invade to foster tumor metastasis. The arrest of cancer cells is favored by permissive flow forces and geometrical constraints. Through the use of high-throughput microfluidic devices designed to mimic capillary-sized vessels, we applied...
The interplay between mechanical forces that result in kidney epithelial fluid transport is not fully understood. In this week's research highlight, we will introduce a recent microfluidic advancement published in Nature Communications that investigates how renal epithelial cells can serve actively as cellular pumps and...
Abstract "Pathophysiological landmarks of depressive disorders are chronic low-grade inflammation and elevated glucocorticoid output. Both can potentially interfere with cytoskeleton organization, cell membrane bending and cell function, suggesting altered cell morpho-rheological properties like cell deformability and other cell mechanical features in depressive disorders. We performed a...