"Homing of circulating tumour cells (CTC) at distant sites represents a critical event in metastasis dissemination. In addition to physical entrapment, probably responsible of the majority of the homing events, the vascular system provides with geometrical factors that govern the flow biomechanics and impact on...
The unique features of microfluidic diagnostics chips such as modularity, portability, low reagent and sample consumption, and high sensitivity make these microchips suitable for point of care applications. In this week's research highlight, we will introduce a microfluidic chip that is capable of multiplexed diagnosis...
"Enzymes are represented across a vast space of protein sequences and structural forms and have activities that far exceed the best chemical catalysts; however, engineering them to have novel or enhanced activity is limited by technologies for sensing product formation. Here, we describe a general...
Wearable microfluidics is a hot topic of research with a promising potential for commercialization. Small and skin-friendly microfluidic devices can collect sweat from the skin and deliver it through a network of microfluidic channels to microchambers where they can undergo a chemical or biological reaction...
"To migrate efficiently to target locations, cells must integrate receptor inputs while maintaining polarity: a distinct front that leads and a rear that follows. Here we investigate what is necessary to overwrite pre-existing front-rear polarity in neutrophil-like HL60 cells migrating inside straight microfluidic channels. Using...