"Antimicrobial resistance challenges the ability of modern medicine to contain infections. Given the dire need for new antimicrobials, polypeptide antibiotics hold particular promise. These agents hit multiple targets in bacteria starting with their most exposed regions—their membranes. However, suitable approaches to quantify the efficacy of...
"Platelet adhesion and activation are mediated by integrin αIIbβ3 clustering, which is crucial for the hemostatic function of platelets. In an activated state, integrins provide the connection between the extracellular matrix and the actin cytoskeleton through a variety of cytoplasmic proteins, such as talin. Here,...
As droplet microfluidics progresses, more sophisticated applications get developed by researchers which in turn require more complex techniques for manipulation. One class of such droplets is endoskeletal droplets. Endoskeletal droplets are complex colloids in which a solid phase is cast within a liquid emulsion. This...
In the ever-evolving field of microfluidics, researchers are continually pushing the boundaries to understand complex biological phenomena. One such groundbreaking study, recently published, delves deep into the intricate pathways of multiple myeloma (MM) cancer cells within the bone marrow using a meticulously engineered microfluidic chip. Microfluidic...
Recent technological developments including microfluidics have facilitated genome-wide transcriptional profiling in select brain regions. These studies can be employed to discover correlations between altered transcriptional activity across brain regions with stress-related mood disordered leading to a better understanding of the molecular underlying driving mechanisms. Here,...