Understanding the dynamic transitions of cell states has been a formidable challenge in cellular biology. Traditional methods have struggled to capture these intricate processes at a single-cell level. A recent study published in Cell introduces a new approach that leverages microfluidic technology to map transcriptomic...
Innovations in gene editing are critical for advancing biological research and biotechnology. A recent study published in Microsystems & Nanoengineering presents a groundbreaking method that combines CRISPR technology with droplet microfluidics, significantly advancing the field of genetic engineering. "We present a droplet-based microfluidic system that enables...
"Mosquito bites transmit a number of pathogens via salivary droplets deposited during blood-feeding, resulting in potentially fatal diseases. Little is known about the genomic content of these nanodroplets, including the transmission dynamics of live pathogens. Here we introduce Vectorchip, a low-cost, scalable microfluidic platform enabling...
"Antimicrobial resistance challenges the ability of modern medicine to contain infections. Given the dire need for new antimicrobials, polypeptide antibiotics hold particular promise. These agents hit multiple targets in bacteria starting with their most exposed regions—their membranes. However, suitable approaches to quantify the efficacy of...
"Platelet adhesion and activation are mediated by integrin αIIbβ3 clustering, which is crucial for the hemostatic function of platelets. In an activated state, integrins provide the connection between the extracellular matrix and the actin cytoskeleton through a variety of cytoplasmic proteins, such as talin. Here,...