Abstract "Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, high-throughput combinatorial screens directly on patient biopsies. However, such screens require a...
Although the majority of microfluidics research has focused on human health, there is great potential for microfluidics in the agriculture sector. For this week's research highlight, we have selected a recent article published in the Lab On a Chip journal in which an integrated microfluidic...
Abstract "Microfluidic designs are versatile examples of technology miniaturisation that find their applications in various cell biology research, especially to investigate the influence of environmental signals on cellular response dynamics. Multicellular systems operate in intricate cellular microenvironments where environmental signals govern well-orchestrated and robust responses, the...
Abstract "Oxidative stress is one of the key factors that leads to red blood cells (RBCs) aging, and impairs their biomechanics and oxygen delivery. It occurs during numerous pathological processes and causes anaemia, one of the most frequent side effects of cancer chemotherapy. Here, we used...
Biological systems are regulated through networks of highly complex behaviors. Bottom-up synthetic biology provides a means for deconvoluting the underlying architecture governing these network-based behaviours. Droplet microfluidics has been the gold standard for creating complex synthetic cells from the bottom-up. To better design such systems,...