Circulating tumor cells (CTCs) isolated from blood have high potentials to be used for early diagnosis of cancer as well as personalized treatment. However, CTCs are rare in the blood which hinders their widespread use for clinical applications. Microfluidic methods for isolating CTC have been...
Abstract "Microfluidic-based cell culture allows for precise spatio-temporal regulation of microenvironment, live cell imaging and better recapitulation of physiological conditions, while minimizing reagents’ consumption. Despite their usefulness, most microfluidic systems are designed with one specific application in mind and usually require specialized equipment and expertise for...
Drug delivery systems aim at the controlled release and targeted delivery of pharmaceutical compounds to the body. With the advances made in miniaturized devices and microfluidic flow control systems, we are steps closer to fully automated microfluidic drug delivery systems with real-time monitoring capabilities. For...
Abstract "Herpes simplex virus (HSV) naturally infects skin and mucosal surfaces, causing lifelong recurrent disease worldwide, with no cure or vaccine. Biomimetic human tissue and organ platforms provide attractive alternatives over animal models to recapitulate human diseases. Combining prevascularization and microfluidic approaches, we present a vascularized,...
The spatial organization and cellular microenvironment of the cells can be very important when it comes to RNA sequencing. Therefore, preserving the spatial organization of the cells and monitoring the changes in the cellular surrounding can be crucial for transcriptomic profiling. Droplet-based microfluidics is an...