Recreating the complex mechanical environment of the human lung alveoli in vitro has long been a challenge. Traditional lung-on-chip microfluidic models sometimes fail to fully capture the three-dimensional dynamics of breathing, often relying on overly simplified or non-physiological stretch patterns. Moreover, these systems typically...
Neutrophils, the most abundant immune cells in human blood, play a puzzling dual role in cancer. While some neutrophils (N1) attack tumor cells, others (N2) actually aid tumor progression by supporting invasion and metastasis. Translating insights from animal models to humans has been challenging...
Biomolecular condensates, membraneless structures formed through phase separation of proteins and nucleic acids, play a central role in regulating key cellular processes. Over time, however, some of these condensates lose their liquid-like nature and begin to solidify, a transformation that has been linked to...
Biofilms, dense microbial communities on medical devices and tissues, are notoriously resistant to antibiotics, causing persistent infections that account for many of chronic cases. Traditional lab methods often miss key aspects of biofilm behavior, including persistence, regrowth, and migration, making it difficult to design...
Tracking how our bodies respond to food, exercise, and stress requires tools that can capture rapid metabolic changes as they occur. Traditional blood or urine sampling provides only snapshots, missing the continuous fluctuations that shape individual health. Sweat is an attractive alternative because it...